Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

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Layout:
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PRKN ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20940148 18599482
PRKN UBE2L3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8214014 21694720
RPS27A PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26161729 24856362
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
H2AP ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
C7ORF31 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
C7ORF31 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CUL1 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CUL1 CHEK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17290223 5219620
NEDD8 CUL1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 0806155105 18723677
PALS1 UBQLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PALS1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PALS1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UFD1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
H3C2 XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
H3C2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
H3C2 KAT2B â—¼   ACETYLATION ✅ 2.0 0.8 Reactome 23667505 23555303
CREBBP H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056256
RUSC1-AS1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RUSC1-AS1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PHAF1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
AAMDC HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AAMDC ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AAMDC GDAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ABHD17C ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ABHD17C HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 AKR7A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AMFR UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TGFBR2 ARFGAP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAD23A ARFGAP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SERPINH1 ARFGAP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARFGAP3 DYNC1H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARFGAP3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARFGAP3 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARHGAP19 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
SELE ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SPATA2L ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC10 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBQLN1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYLIP ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAD23A ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
CRLF3 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NUP43 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GORASP2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
USP13 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DCLRE1B ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LHX6 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FOXD4L6 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BCHE ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NR0B2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TBX22 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EWSR1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAD23B ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
TEX19 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MKRN3 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SLC52A3 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FEZ2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TLR10 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LDHAL6B ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WWP1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KLHL20 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GDAP1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZNF366 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
POC1A ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZMAT2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EDRF1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VPS37A ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDKAL1 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RNF31 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
METTL7A ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
C16ORF54 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VCP ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16525503 5218414
CLPP ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PARVA ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TELO2 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STK36 ATXN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 PSMD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 TDP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 CCT6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
ATXN3 FANCG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 MICAL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 IGFBP4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 SERPINH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN3 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATXN3 SOX14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CAPN2 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12000759
BECN1 USP13 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21962518 22216260
TRAF6 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20501938
BMX TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217965 16186805
PRKACA CAPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11909964 29478550
HTT CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16777606 10770929
CASP3 PTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23074268 12907805
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
NEDD8 CASP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8373364 22584050
CASP7 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA CCT6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGFBR2 CCT6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CHEK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
CLPP GDAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CLPP HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CREB1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20629536 10567368
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
EWSR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8552387 12459554
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
HSPA1A DCLRE1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19411856
DCLRE1B HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
EDRF1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WWP1 EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RAD23A EWSR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FEZ2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FOXD4L6 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GDAP1 VPS37A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC10 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NR0B2 HDAC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17895379 0706736104
HDAC3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16847267 0510834103
HDAC6 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC6 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
HDAC6 TUBA4A â—¼   COLOCALIZATION 2.0 0.8 intact 5215415 12024216
TUBA1A HDAC6 â—¼   DEACETYLATION ✅ 2.0 0.8 intact 5215415 12024216
HDAC6 TUBA4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12024216
HTT HSPA1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPA1A SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TUBA1A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KLHL20 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TBX22 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RPS27A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZNF366 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VCP HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PSMD7 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
POC1A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SPATA2L HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LDHAL6B HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
LHX6 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IMMT HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VPS37A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAD23A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STUB1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SUMO1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT SPATA2L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT SOX14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT MICAL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT IGFBP4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA IMMT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27153535
KLF4 SELE â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24470523 17209004
TP53 KLF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10749849 16713569
PML KLHL20 â—¼   COLOCALIZATION 2.0 0.8 intact 20389280 7900485
LAMTOR1 UBQLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STUB1 LIG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18313385
MAP1LC3A SQSTM1 â—¼   COLOCALIZATION 2.0 0.8 intact 19427866 7034152
SUMO1 MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
UBQLN1 PARVA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
PNKP UBQLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PSMC5 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PSMD7 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SQSTM1 RAD23A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RAD23B SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23751493 26151477
RHEB UBQLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RNF31 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
RNF8 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
RPS27A TDP2 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
SQSTM1 TUBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2L3 STUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 STUB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21478269 17666403
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
SYVN1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 17170702 5219455
TDP2 UBC â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TDP2 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TDP2 UBA52 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
VCP TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TUBB2B TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
WWP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
CREB1 TP53 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
TRAF6 GSK3B â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 30711629 30806153 31594754 31754475
NPLOC4 UFD1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 20414249 7903886
ITCH RPS27A â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
RAD23B UBQLN1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
UBC SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5216530 12857745
ITCH TRAF6 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
AMFR UBB â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
CUL1 DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22474075 21145461
BECN1 DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25499913 23974797
TRAF6 DDB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25499913 17353931
HDAC6 EP300 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15102857 19344692 12718889 22778253 23133622
FANCG UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RHEB UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SOX2 SUMO1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25416956 17097055
TUBA1A TUBA4A â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
RNF31 UBB â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
UBAC1 UBB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
RPS27A UBE2S â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
OTUB2 TRAF6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 23105109 32296183 19996094
SOX2 SOX14 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
BECN1 TRAF6 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
SPRTN UBC â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
TUBA1A TUBB â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
CUL1 UBB â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CHEK1 CUL4A â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
PSMC5 VCP â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
EP300 XRCC6 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21988832 15023334 33742100
HDAC3 NR0B2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15835920 17895379
HTT SQSTM1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
UBA52 UBE2S â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
HDAC6 UBB â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
OTUB2 RPS27A â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
PSMC5 RAD23A â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
NEDD8 UBB â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
PSMC5 RAD23B â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RPS27A UBQLN1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CUL1 VCP â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
PSMD7 VCP â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
TUBA4A TUBB â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
HDAC6 RPS27A â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
UBE4B UBQLN1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
TRAF6 UBE2L3 â—¼   PHYSICAL_INTERACTION 859.0 0.85 STRING 36370105
EP300 KLF4 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
SOX2 PIAS1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 35140242 23667531
RNF8 UBE2D3 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
ATXN3 UBB â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
CHEK1 DDB1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
OTUB2 UBB â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
DYNC1H1 TUBA1A â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMC5 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMD7 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
PSMD7 UBC â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CUL4A CUL1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 17079684 32235678 21145461
SOX2 HDAC3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 23667531 21532573
SOX2 NCOR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 28794006 23667531 21532573
DYNC1H1 TUBB2B â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
HSP90AA1 HSPA1A â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CREBBP HTT â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CREBBP KLF4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMC5 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PSMD7 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ITCH UBE2D3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIAS1 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
RAD23B UBE4B â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
RAD23B UBB â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC6 SQSTM1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATXN3 RAD23A â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CHEK1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
TUBB3 TUBB4B â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
RAD23A UBQLN1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HAP1 HTT â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
PML HDAC3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 16189514 11259576
ATXN3 STUB1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
RNF31 UBE2L3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CREBBP KAT2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 TUBA1A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SPRTN VCP â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CREB1 EP300 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
HTT VCP â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
UBE2D3 UBE4B â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
KAT2B EP300 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12888487 22384255 9267036 12419806 21413932 20870727 33051058 8684459
UBC UBE2D3 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
NEDD8 UBA52 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
PARK2 UBE2D3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CUL1 RPS27A â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
AMFR RPS27A â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
ITCH UBC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
STUB1 TP53 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CUL4A NEDD8 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
RNF31 RPS27A â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
PSMC5 UBC â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
UBA52 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24784582 26161729 24856362
TUBA1A GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UFD1 SPRTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22902628 23042605 23042607
UFD1 TP53 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PRKACA H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11749379 9892015
KAT2B H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 34811519 16096646
PRKACA ARHGDIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18768928
BCL2L1 EDRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CREB1 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11450946 16205321 18830594
CAPN1 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12000759
CREB1 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15126506
HDAC3 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16528103 18241676
CREBBP FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15126506 10973497
CSNK2B TUBB2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
EP300 KPNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10801418 15342649
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
EWSR1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10749119 14534527 10508522
GABARAP SQSTM1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
TP53 HSPA1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7811761 16713569 8729618
HSPA1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7811761 16713569 8729618
RNF8 MDC1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24240613 25512560 18001825 26734725 18001824 18006705 28943310
NCOR1 PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10882117 16713569 11430826
VCP NPLOC4 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 20414249 7903886
SUMO1 PML â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15017387 15561718 28851805 16501610 19217413 22155184 22875967 24654937 31879127 21779164 20188669 9885291 9452416 17081986 21098080 22406621 18625722 21305000 17344210 17027752 11160742 19380586 23604351 23830076 17081985 9427741 11080164 16189514 23028697 21057547 19015637 20972456 8806687 20826694 24190887 25497731 17036045 11948183 9756909 18474224
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
RAD23A UBA52 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
VCP SPRTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22902628 23042605 23042607
SUMO1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18093978
TP53 SYVN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
UBE2D3 TUBA1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UBE2D3 UBA52 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MDC1 BCL2L1 â—¼   KO_UP_REGULATES ✅ + 0.9 0.9 PKG 28854368
STUB1 UBE2W â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PARK2 UBA52 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
PSMC5 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
PSMD7 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
KAT2B TP53 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
TUBA1A TUBB2B â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
BCL2L1 BECN1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
PARK2 RPS27A â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
PIAS1 SUMO1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
TUBB TUBB3 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
HSPA1A STUB1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
RAD23A RPS27A â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
TUBA4A TUBB3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
HSP90AA1 STUB1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
SQSTM1 TRAF6 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
RPS27A TRAF6 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CUL1 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
NEDD8 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
SQSTM1 UBC â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
AMFR VCP â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
MAP1LC3A SQSTM1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
NEDD8 RPS27A â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
UBC VCP â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
UBE2L3 WWP1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ATXN3 RPS27A â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
RAD23A UBB â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
ATXN3 RAB28 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
NPLOC4 UBC â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
OTUB2 UBA52 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
UBB UBE2S â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
RAB28 TUBB â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
RAB28 RAP2A â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
RAD23B UBC â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
SQSTM1 MAP1LC3A â—¼   COLOCALIZATION ✅ 0.95 0.95 mint 19427866 7034152
UBC UBQLN1 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
PARK2 UBB â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
RRAGC RRAGA â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 25936802 25567906 33961781 22424946 23184942 20381137 25561175 31601708 33157014 26186194 16713569 11073942 21981924 28514442 21816923 24337580 16189514 28716898
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
TUBA1A TUBB3 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CREBBP SUMO1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
ITCH UBE2L3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
STUB1 UBE2D3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
NEDD8 CUL1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21765416 16177058 18723677 18627766 17438373 32726803 24654937 11027288 18274552 10772955 16503656 24076655 18247557 22405651 17318178 10713156 19713960 10318914 21102408 23267066 23201271 22959436 17206147 16620772 18805092 10597293 21119685 21145461 18826954 19245792 19617556 12565873 18264111 24949976 22474075
TDP2 NDUFA4 â—¼   KO_DOWN_REGULATES ✅ - -0.98 0.97 PKG 28854368
HDAC6 UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
UBE4B VCP â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
UBC UBE2S â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
BCL2L1 TP53 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
PML SUMO1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
AMFR UBC â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
ATXN3 VCP â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RNF31 UBC â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
OTUB2 UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
ATXN3 UBC â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREB1 CREBBP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
RPS27A TP53 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
SYVN1 VCP â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
RAD23A UBC â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PARK2 UBE2L3 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPS27A UBA52 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PSMC5 PSMD7 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR1 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NPLOC4 VCP â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RRAGA RRAGC â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
UBC PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 24784582 26162776 26161729 25847540 24751536 26254304 23670163 26116755 27284007 25474007 26260794 22724072 25969509 24856362
PRKACA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 16543730 15845746 18691976 19836308 8524413 12054501 16039586 12147701 16522636 11035810 18669648
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
GSK3B CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16568235 12162494
GSK3B ATXN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 30283301 28408866 17434145 21900206
CUL1 NEDD8 â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
CUL1 NEDD8 â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
CUL1 NEDD8 â—¼   ENZYMATIC_REACTION ✅ 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
NEDD8 CUL4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9694792 18805092 21145461 19250909 19231300
VCP UFD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23443559 16234241 26389662 16525503 18775313 26712280 27913212 15371428 20414249 26549226 16822850 18199748 23333620 17872946 19275885 24248593 20442859 27226613
NPLOC4 UFD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16322459 18775313 18586029 15371428 20414249 26389662 36087575 32296183 17202270 24248593 20442859 11574150
CHEK1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18451105 20068082 23844048 12560483 18066052 20948546 21357687 18243098
HDAC3 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19442252 16865259
EP300 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21875947 19270680 19158375 20587414
AMFR VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20126661 22328510 16407162 16987818 17681147 26712280 16275660 21636303 17872946 18835813 19828134 22119785 23333620 23383273 26424800 21343306 21914798 16186510 15331598 17311810
TP53 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869582 9582400 9989972 11713584 18172861 23519249 12705879 9000137 11713302
TP53 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
BCL2L1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
BCL2L1 BECN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 33931087 19180116 19049976 22219388 18628207 18641390 17659302 9765397 16713569 19713971 24443581 17446862 17337444
PRKACA CAPN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11909964
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
CHEK1 FANCG â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17582221 18677104 18931676 19686080 19793801
TP53 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21546904 11158294 20190799 19435816 18632613 15016801 19395378 11152453 18753293
CHEK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 20950777 18778462 25545885 18677104 20860841 15798197 19793801 22891162 16511572 23852422 16713569 15865930 11551930 19923893 15467443 11709713 21748595 17116885 15659650 17582221 26384650 10673501 17384638 23966620 23892398 17118344 9765199 15140942 19788416 10801407 18319725 12781359 12897801 25823026 15459660 23296650 15024084 17296725 17102137 11896572 17339337 19933256 20526329 28140789
CHEK1 FANCG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17296725 19686080 18677104 15798197 17102137 17116885 17582221 19793801 17384638 18931676 15459660
CREB1 PRKACA â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 19244110 12150772 12082174 2573431 9733829 17908236 15879576
PRKACA CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11175347 12356771 15733869 11160957 21902831 2885756 2875459 7958915 9829964 12235136 12763014 9687510 8887554 15568017 11698596 8688081 9528766 11018520 11969286 11909979 8336722
CREB1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16611888 25241761 21295542
CREB1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 10866654 18599546 15585582 7870178 8028671 11313407 16007092 8413673 11564156 15691881 9829964 15073328 20403362 11259575 17476304 17707401 20541704 16799563 7870179 11123304 27789289 7913207 12933667 8663317 8004670 11483993 12198160 9413984
NCOR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20462215 17400812 12392082 10612426
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
KAT2B CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9687573 8684459 9687513 9445475 11864601 9267036 17496784
HTT CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11264541 11607033 16456924 15994095 17500595 16713569 10823891
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
HDAC3 NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
HDAC3 NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 HDAC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11509652 11013263 16195251 11931768 16469706 21258344 17694085 10860984 16917504 10944117 23752268 16713569 14527417 11466315 11804585 12628926 15601853
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSPA1A HSPH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8721986 18550409 9873016 7585962 9305631
TP53 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22399227 15996546 16978870 16278683
TP53 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18431400 32814053 16713569 10823891
TP53 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9266967 20094059 15153330 17611664 18945670 14614455 17293853
KAT2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19680552 11804596 12068014 16537920 9891054 10490106 14614455 20589832 19788416 12660246 12501250 16959611 19407812 9744860 15965232 16678111 17977830 17189186
KLF4 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18511453 16244670 17308127 21132436 17659301
MAP1LC3A SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 20061800 23022382 23459205 35044719 22963397 36036324 31053714 21045561 25921531 19250911 17580304 21628531 20204693 28740232 23640897 25686248 24100292 26075355 20562859 22658522 25984893 21460636 16286508 19427866 32296183 23989536 19021777 26268733 22714671 24998849 18653543 31366950 33436498 16169070 23239879 26754771
XRCC6 MDC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MDC1 RNF8 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 12607003 15279786 15459660 15496928 15549137 15655342 17303408 17660363 18001824 18001825 18006705 18087291 18171670 18212739 18583988 18590585 18678709 18678890 18809224 19217833 19270065 19490890 19772495 20021983 20064462 7575488 9407949
MDC1 RNF8 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12607003 15279786 15459660 15496928 15549137 15655342 17303408 17660363 18001824 18001825 18006705 18087291 18171670 18212739 18583988 18590585 18678709 18678890 18809224 19217833 19270065 19490890 19772495 20021983 20064462 7575488 9407949
MDC1 RNF8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 24240613 18001824 25512560 18001825 18678647 18082599 18006705
VCP NPLOC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 34262183 31623962 20442859 32814053
OTUB2 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23105109 19996094
PIAS1 SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16524884 22578841 19217413 18806873 14609633 11583632
PIAS1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 15133049 10380882 20805487 11867732 16713569 11583632 11788578
SUMO1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22875967 9756909 25497731 17036045 21057547 18931695 19217413 8806687 16189514 17081985 11080164 11948183 9885291 19380586 17344210
RNF8 XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TRAF6 SQSTM1 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
TRAF6 SQSTM1 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11274345 12620219 14660645 15125833 15340068 15721744 16252010 17948050 18264787 18758450 18922473 19161412 20531300 21981924 25002027 26587781 28574505
SQSTM1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15870274 27458013 10747026 27681126 16079148 16189514 18382763 16874300 11244088 17389358
TGFBR2 TRAF6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 11013220 11133108 12154066 12717440 12724770 12767520 12809600 14557817 15265520 15548370 16474430 17673906 17934056 18758450 18922473 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 22943793 24132110 24336330 7594497 9865696
TGFBR2 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 12717440 19050695 11133108 14557817 19920116 22710166 19114990 12767520 22703233 23331499 11013220 20060931 17934056 21614932 17673906 20644162 24132110 18922473 9865696 22943793 20519943 21900405 12154066 7594497 18758450 15548370 24336330 21278795 12724770 19010789 15265520 16474430 26192618 12809600 19109155
TLR10 TRAF6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8837778 12138165 18070982 12140561
TP53 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18172499 18695251 24667498 22056774 17290220 17592138 12421820 18413597 20173098 19556538 21857681 17470788 18359851 19805293 19196987 12640129
MDC1 CAPN2 â—¼   KO_UP_REGULATES ✅ + 1.25 1.25 PKG 28854368
TDP2 TDP2 â—¼   KO_DOWN_REGULATES ✅ - -2.0 1.99 PKG 28854368
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368