Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TP53 RACK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16980608
H2AC12 BIRC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
AP3B1 OPTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NUMA1 BIRC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
GOLGB1 BIRC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RRBP1 BIRC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
BIRC6 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15200957
CASP9 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
CASP3 CASP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 12011067 15573119
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP9 CASP7 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
CASP8 PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP9 DIABLO â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14960576 11084335
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
EIF2B5 DYNC1H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
GOLGB1 GOLGA4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
MOS MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7731726 7873542
RASSF2 OPTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PLK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 7266226 19833129
TP53 PRKAA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
SNAP29 STX17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 23466629 23578367
SNAP29 STX17 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 23466629 23578367
TP53 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
TP53 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23995788 21317932
EIF4A1 RPS2 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
GABARAP STX17 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
BIRC6 CASP3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 15200957 15507451
GCN1L1 NAA25 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
PRS8 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CK5P2 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29162697 34079125
RBP1 CK5P2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MLP3B CASP8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21900206 30941888
FERM2 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
AP3M1 FERM2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CCD22 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ATS4 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
DCA12 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ANGL3 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
UGGG2 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
OSBL2 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
AGRP BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
AKAP9 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RBP1 BIRC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 31980649
DISC1 EXOC4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17043677 31413325
EEF2 ETF1 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
DYNC1H1 UBR4 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
OPTN RAB11A â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
VEGFD UBR4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
VEGFD BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
PRS8 RBP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 31980649
UBP8 BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25733871 26683461 18329369
FA58A BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CC020 BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHIA BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
HERC2 BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 25476789
MOS BIRC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CHIA UBR4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
PLK1 TBK1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 25659891
BIRC6 MLP3B â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31692446 33545068 31213539
MLP3B TBK1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33545068 21617041
CASP8 RBP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 12887920 16227629
ETF1 RPS2 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
CASP9 CASP3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 1067155 11242052 11230124 18723680 25241761 15941357 17437405 8900201 15507451
TP53 UBE2D1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
BIRC6 HTRA2 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
BIRC6 PLK1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 26496610 18329369
RRBP1 DISC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29961565 31413325
IPO9 DISC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 29961565 31413325
BIRC6 RNF41 â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
AP3M1 AP3D1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 23144738 26344197 28514442 22863883
MGST3 BIRC6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 29568061 28514442 33961781
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11832478 11437602 8962078 18669646 15254227
CASP3 CASP9 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HERC2 DISC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 17043677 31413325 90000000
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
OPTN RAB8A â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AP3D1 AP3M1 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
HTRA2 DBLOH â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11606597 11604410 16713569 32877691 16189514
CK5P2 AKAP9 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20466722 26297806 29162697 34079125
RNF41 BIRC6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 14765125 29560723 31213539 15314180
ABCE1 NAA15 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
BIRC6 DIABLO â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RNF41 USP8 â—¼   UBIQUITINATION ✅ - 0.88 0.88 Signor 23750007
USP8 RNF41 â—¼   DEUBIQUITINATION ✅ + 0.88 0.88 Signor 23750007
BIRC6 DBLOH â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 15200957 24302728 22788920 20957035 32877691 15300255 28514442 15781261 15507451
MLP3B OPTN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30679426 32296703 25026213 21617041 23805866
AKAP9 DISC1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 29961565 17043677 31413325 90000000
AP3B1 AP3M1 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
AP3B1 AP3D1 â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
RNF41 UBP8 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15314180 23750007 17035239 28973533 29560723
BIRC6 DIABLO â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 14765125 15300255 15781261
CASP3 DIABLO â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14960576 11257231 9230442
TBK1 OPTN â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 18307994 6492190
RPS2 RPS3 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
ABCE1 RPS3 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
EEF2 RPS3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ANAPC11 UBE2D1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
ABCE1 RPS2 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
AP3B1 AP3M1 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
ABCE1 ETF1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
AP3D1 AP3M1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
AP3B1 AP3D1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
MAP1LC3B OPTN â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
RNF41 USP8 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
OPTN TBK1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
EEF2 RPS2 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
RPS2 RPS3 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ANAPC11 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
DYRK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 29296831 21383696 14749479 11740489 20171273 25778922 15843377 33906076 10581258 15750624 15897882 15706352 26236013 24899407 33572115 17906639 20935676 24379358 17386256 15870257 26346493 12427754 34103685 17567906 11101524 17210684 18536714 15381073 19965871 26578795 26087959 28060750 21765464 20673369 34216619 16601678 17380123 33443163 18216278 21642861 15526030 22878263 17349959 16738336 20696760 19882354 16219768 17105820 16793543 17332358 24901999 16247456 24196445 26804244 15657359 27208501 18056705 21765463 23420876 22797063 16377624 19861417 18160537 12676607 20123963 15489221 17591690 20514025 23149944 19857493 17891183 27034505 11780126 21057547 25944899 26341817 17349958 20962272 22525275 19828042 12902982 19465479 15471885 15322239 11495913 12907596 32083004 25915850 20018442 24145406 26029824 21394211 12093737 33872315 20610713 20024960 26113041 20811699 18560558 21660965 16717128 11030628 17107963
HTRA2 CLEAVED~BIRC6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005
PLK1 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19686080 19270156 18931676 19622404
AURKB TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 20959462 27933271 20847049 15469940 32873634 22611192 27496712
AURKB KIF23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15630414 30728176 16461284 25512391 19203582 15854913 20451386
HTRA2 BIRC6 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005
HTRA2 BIRC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15781261 15300255 16713569 15200957
CASP3 BIRC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15507451 15200957
BIRC6 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15300255
BIRC6 DIABLO â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15300255 15507451 22788920 15200957
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
CASP9 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10708865 9390557 10508159 11230124 18723680 15657060 16977332 15507451 1067155 9708736 25241761 8900201 11242052 9765224 17437405 19788417 9812896 12620238 15941357 12181739 19465923 12792650 15725726
CASP3 NUMA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9463409 17401638
CASP7 DIABLO â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14960576 11257231 18619610 9230442
CASP7 CASP9 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 16916640 9922454 11752425 11701129 12824163
CASP9 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17899380 9922454 16352606 9598997 9651578
CASP8 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18073771 9545235 10872455 18329793 9727491 9463409
MAP2K1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12792650 18669648
TP53 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16931621 8270002 9275177 19671680 16571800 8641461 9360984 21952947
CCNA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14640983 10884347 16713569
PLK1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18931676 16565220 19270156 19622404 19686080 14657031
CSNK2A1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21209074
CSNK2A1 EIF2B5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11500362 18669648
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2A1 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15822905 17081983 16565220 18088087 29854279 2492519 34359868 25995454 1956339 16094384 15581363 18591256 16964243 92065884 15302935
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
PLK1 OPTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 27247382 26365381 26376340 22365832 34099552 29867991 27035970 26266977 21862579 25923723 21617041
TBK1 OPTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 27247382 29246869 29594070 27035970 21617041 18307994 22364875 29755463 21903422 26376340 29867991 23794264 26101267 26365381 21862579 27538435 25026213 25923723 29282133 29626651 29971063 30294276 30223576 20174559 26266977 23414517 27086836 23178947 22518139 27906974 25803835
TP53 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17172872 17981789 15024021 22405092 20962589 24076372 23948487 15016801 22184120 19713933 16369493 23474762
PLK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22653443 19833129 16753148 23948487
PRKAA1 STK11 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 14511394 15579580 8779952 14985505 14614828 11018120
STK11 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 16434556 25792737 14985505 14976552 20489196 21062936 20656472 20616029 17255104 16041368 25696921 21399626 12391032 20160076 17244528 15980064 17054914 22517326 14532170 21918180 28694351 18693249 26771234 20801214 16600998 18195011 28723898 16912160 22039048 26068970 14614828 19884317 25679763 22575644 19197243 27864418 30022161 25683918 18303014 17287464 15327994 12764152 16054095 15509864 26506235 14511394 27181208 28625738 25874865 8910387 17276402 26247630 21680840 19414597 23418352 24289924 15383373
PRKAA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28797070 15866171
RAB8A RAB11A â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 20308558 22433857 22983554 12221131 23567335 21273506
USP8 RNF41 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15314180 23750007 17035239
STK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20815019 11430832 17108107 16713569
UBE2D1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
VHL UBE2D1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499