Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GATA6 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11585914 9832509
TLE5 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TLE5 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TLE5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20676368
PRKACA ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZHX3 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
NLK ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
UBAP2L ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
CREBBP FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10973497
CREBBP TCF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9774110 9388250
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
CSRP3 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NLK CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12556497
CTNNB1 TCF7L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11136974 11266540
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
FOXO1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25510553 19049975
FOXO3 FOXP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20439537 20467422
STAT5A FOXP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17182565 24298014
FOXP3 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18008005 24155921
TLE1 GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 HIPK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217735 15896780
TAB1 HIPK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 10391247 15082531
MDM2 HIPK2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16212962 5217983
HNF4A TCF7L2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951069
PRKACA HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RANGAP1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NLK HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT PKM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TCF7 LEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
LEF1 TCF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8479911
TP53 MAP1B â—¼   COLOCALIZATION 2.0 0.8 intact 18656471 6700545
TP53 NFATC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14990988
PASK NFATC4 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 21418524 8145255
PRKACA NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10611249 11749379
WNT5A NLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 20706670
RCHY1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 5220017 17568776
TCF7L2 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18602747
TCF7L2 TCF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15473860 10489374
TP53 TCF7L2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14990988
TCF7L2 TLE3 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
CREBBP TCF4 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
FOXO3 TP53 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
MDM2 KPYM â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24583282 27264869 20195357
CREBBP FOXO1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
SKP2 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 6540196 18239684
NLK SHAN2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 23602568
NLK CB044 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 23602568
NLK CNOT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 23602568
TAB1 MAP3K7 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5218828 16845370
NLK TRPS1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 23602568
CUL1 FBXW4 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
MAP3K7 NLK â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
CREBBP FOXO3 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
CTBP1 CB044 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 35016035 26186194 28514442 31041561
CTBP1 TRPS1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 35016035 26186194 28514442 31041561
CTNNB1 PPARG â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
FOXP3 STAT3 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
FOXO1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
NLK TCF7L2 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
FBXW4 CUL1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29103612 25143387 14603323 25515538 23658844
FOXO3 MDM2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
SMAD4 SKP2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 15314162 16865698
CREBBP TCF3 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CTNNB1 TCF7 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
MDM2 CUL1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24804778 20708156
M3K7 STAT3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15764709 32229191 3031469
HLCS KRTAP5-9 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
CREBBP MDM2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
NLK KPYM â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 23602568 24606918
NLK F222A â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 23602568
HNF4A FOXO1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12519792 19740748
FOXO1 PRKACA â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CREBBP HTT â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CNOT11 CNOT2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIPK2 TP53 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CUL1 FBXW5 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CTNNB1 TCF7L1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
NLK M3K7 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15764709 25241761 20194509
FOXO3 SMAD4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15084259 21532621
MDM2 FOXO4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 20874444 21525355 18665269
SMAD4 NLK â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 23602568 21988832
CCP110 CEP97 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
RCHY1 TP53 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
FBXW5 CUL1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 29103612 25143387 14603323 25515538 21145461 23314863 23319600
HIPK2 MDM2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16212962 23826318 17349959
NLK LEF1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12556497 24394665 20194509 12901858
TP53 RCHY1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 17568776 5220017
TP53 RCHY1 â—¼   COLOCALIZATION ✅ 0.89 0.89 mint 17568776 5220017
TAB1 TAB2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
WDCP TAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CREBBP HNF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10777539
CREBBP FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15126506 10973497
CREBBP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649887 11773079
STAT3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20830236
CTNNB1 TCF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15473860 17724465 10489374
CTNNB1 HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12944908 25241761
DAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17339337
HIPK2 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16212962
RANBP2 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9398662 10473610
TCF7 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15473860 17335794 11326276
MYBL2 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7655015
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
SMAD4 SKI â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 14699069 15231748 25670202 15761153 20959473 31932471 28468752 12764135 26977879 12732634 10531062 17469184 12857746 19032343 12419246 25609649 12874272 14525983
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
LEF1 NLK â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
KPNB1 RANBP2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CREBBP CTNNB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CNOT3 CNOT2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5218748 16778766
CTNNB1 TCF4 â—¼   PHYSICAL_INTERACTION 929.0 0.92 STRING 36370105
KRTAP4-2 KRTAP5-6 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
KRTAP4-2 KRTAP5-9 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
TCF4 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
HIPK2 MYB â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 15082531 16055500
CEP97 CCP110 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 22441691 8392017
TLE1 LEF1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 15768032 9751710
KRTAP5-6 KRTAP5-9 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HuRI 32296183
NLK MYB â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 15082531 15308626 16055500
TAB2 M3K7 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 25642820 20538596 16845370 24061540 19026643 31127032 30348973 32303555 16603398 22081109 24270572 17384642 12242293 19955178 22158122 12609980 11259596 28507161 27426733 10882101 34535633 32707033 14633987 26432169 22167179 14743216 32410369 31250519 18021073 20200282 20194509 27468689 14670075 19232515 24912525 33717111 21903422 19556242 8638164 17158449
TCF7L2 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 11713475 5214798
CREBBP PPARG â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CTNNB1 LEF1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CREBBP MYB â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RANBP2 RANGAP1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TAB1 M3K7 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 20538596 16845370 19026643 32303555 32227113 12429732 12242293 22158122 27880917 23934659 28507161 12975377 34535633 32707033 10702308 26432169 22167179 14743216 32410369 16260783 20200282 27468689 12624112 15590691 10838074 14670075 19232515 24912525 33717111 21903422 19556242 25241761 18456659 8638164
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
SKI SMAD4 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MAP3K7 TAB2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CTNNB1 TCF7L2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CNOT2 CNOT3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NOTCH1 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11585921 15546612 11461910 18094723
CUL1 SKP2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CUL1 SKP2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CUL1 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11516665 12820959 15071497 15147722 15340381 15459660 15668399 15688063 18931676 19622404 19686080
CUL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10228155 10713156 10023660
TLE3 TLE5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11290324 15187083 9783587 11266540 8365415 9887105
CTNNB1 CREBBP â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
CREBBP LEF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
CREBBP TCF7L2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
HTT CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11264541 11607033 16456924 15994095 17500595 16713569 10823891
CREBBP MYBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9210395
CREBBP MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8654374 11073948 12196545 16055500 18585056 16799563 23980173 14761981
CREBBP CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10769018 21751375 11973335 17410209 18347063 16476742 23273993
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
HIPK2 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 28532298 14567915 23331499 27689990 19788416 22649776 15708980 22889244 23291169
CTBP1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12711682
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
PPARG CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12021175 15190077 20303941 14764597 19075513
TCF7L2 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24214913 14706452 19347947 24317174
CTNNB1 TCF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12086873 11943708 13679048 15806138
CTNNB1 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17785445 15473860 11326276 17335794 15728254
PRKACA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 33914026 16199882 22173096 21303971 33815677 22094462 17287208 26068882 26884171 33605402 21506126 24117889 12297048 21822311 16476742
CTNNB1 HNF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12107263 11266540 23331499 15055546 16442529
CTNNB1 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12107263 15327769 23331499 9488439 11136974
CTNNB1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17145710 9488439 11713475 12446687 17143293 27902311 16569639 22014570 16724116 11955446 16442529 26350900 19202075 17050667 20126258 22056988 16306047 17914096 19443654 18391971 21670201 22155184 10080941 17283121 16230076 22304967 16630820 15684397 11713476 12861022 19304756 20492721 19816403 18772112
CTNNB1 TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 24532795 11713475 18281465 25402006 16724116 12799378 12944908 12727872 23331499 15060161 17412698 22080605 21743491 17875931 12657632 17983804 20126258 17318191 24798214 24876153 29361949 17909039 23449499 22699938 18595660 9308964 16007074 15331612 11713476 15665104 17072306 15525529 17962194
CTNNB1 TCF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 25678599 19358846 16442529 15735151 17143293 9065401
CTNNB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 15905404 21071413 17254970
CTNNB1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 16510874 23151663 11751639 15735151 17143293 16204248 23331499 12556497 21071413 14638683 15768032 18296023 12748295 21743491 11835406 16510875 18077326 8757136 9065403 20123964 15728254 17517646 21078818 15684397 8892228 10890911 15525529 12077367 9419974
CTNNB1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25721714 16847334 25168821 19495794
CTNNB1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 17254970 15905404
CTNNB1 FOXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17254970 15905404
DAPK3 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15001356 11504915
FBXW5 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17244613 19232515 33962073
SKP2 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11516665 12820959 15071497 15147722 15340381 15459660 15668399 15688063 18931676 19622404 19686080
FOXO3 FOXO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19244250 16100571 18202312 23509296 19690465
HNF4A FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12519792 19740748
SKP2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15340381 17522590 15147722 17646672 12820959 15668399 11516665 15071497 15688063
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
MDM2 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11715018 11779693 11923280 14761977 15024084 15084260 15169778 15876864 16307918 17110379 17158541 19321440 20679392 9450543
MAP3K7 FOXP3 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
WNT5A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16273260 21903638 15578921 17804197 24032637
HIPK2 TCF4 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10391247 11925430 12851404 15082531 17349959 18974774 19828042
HIPK2 NLK â—¼   UP_REGULATES ✅ 8.0 1.0 ACSN 10391247 11925430 12851404 15082531 17349959 18974774 19828042 21118996
TP53 HIPK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16343438 19642869 18809579 18483253 19828042 21248071 18336191 11925430 11740489 11532197 17658469
MAP3K7 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15082531
HIPK2 NLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 14567915 17666529 15082531 15526030 21285352 18974774 15708980 22236966 21118996 20307497
HIPK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 19828042 25210797 20508833 22545114 23814485 19731416 11740489 20171273 11875057 16212962 16729035 23700162 23945296 24101931 27308326 16713569 23536002 28107201 27901482 27019364 19714248 22011578 27308327 15896780 16601678 23316480 24145406 28122345 21192925 17906639 25313037 27689990 20849851 21258400 17203463 19128456 17349959 25364713 11925430 20418953 24829283 22935610 21855806 28893313 23717325 11780126 19946469 21057547 23293771 27787517 26942128 15865933 17210684 17332358 22110707 22889244 23091802 24211575
HIPK2 SKI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 21071413 12874272 18988627
HNF4A HNF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8367288 9111350 9792724 8674436 11717395 9313764 9837989 9204893 9232592 1734282 20850486 8735941 11145965 11085951 10331424 8808405 12601360 16670373
NLK HNF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
TP53 HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11818510 16895524
NLK HNF4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
TP53 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22399227 15996546 16978870 16278683
TP53 HTT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18431400 32814053 16713569 10823891
TAB1 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10089876 10391247 11274345 11796223 12620219 14660645 14741051 15036616 15082531 17593948 18235236 18264787 18855897 19136967 19608982 23070005 2550447 7650486 9973469
TAB2 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10089876 10391247 11274345 11796223 12620219 14660645 14741051 15036616 15082531 17593948 18235236 18264787 18855897 19136967 19608982 23070005 2550447 7650486 9973469
TLE3 LEF1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 10485845 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
TCF7L2 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15473860 20802155 17335794 11326276
SMAD4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
NLK LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 16714285 14960582 23331499 22373574 12482967 12556497 24816797 12901858 11274345 20194509 19623618 18855897
NOTCH1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 11604490 16713569 18988627
LEF1 TLE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 23331499 15768032 9751710
TAB2 MAP3K7 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
TAB2 MAP3K7 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
TAB1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16289117 18180283 10838074 24912525 23934659 10882101 19556242 11259596 19026643 14670075 17299140 23331499 22158122 12372426 21903422 17560374 21071413 23180781 19775907 14743216 17348859 20200282 26432169 18988627 10094049 8638164 11809792 10702308 25241761 19232515 14633987 18456659 10921914 20538596 15590691 16845370 27468689 12975377 12242293 17172402 22167179 12429732 12624112 12859960 16260783 11460167
TAB2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 112.0 1.0 Omnipath 17145710 11477091 17301840 18180283 10838074 24912525 16251197 10882101 19556242 15125833 19955178 31250519 36130827 17363905 17158449 11259596 19026643 24699077 14670075 18641653 24061540 24403530 23331499 22158122 12372426 21903422 27426733 21071413 23180781 14743216 18021073 21133840 20200282 26432169 21232017 18264787 20194509 10391247 18988627 22081109 8638164 16799562 11809792 19232515 12620219 14633987 19161412 20538596 22941947 23681101 20932475 15590691 12609980 16845370 27468689 12242293 11280761 15082531 26192618 14660645 24958845 17172402 15327770 25642820 22167179 20164171 16603398 17384642 11460167 21041997
MAP3K7 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18235236 15036616 18855897 19136967 17593948 11796223 14741051 11274345 2550447 19608982
MAP3K7 NLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17145710 11071635 23331499 15082531 25241761 12482967 15764709 11404460 15640443 20194509 10391247 10823839 7693453 12709429 10377264
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
NLK MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 15308626 15082531 12482967
TAB2 NLK â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 10391247 11274345 12620219 14660645 14960582 15082531 18264787 18855897 20194509 23070005
TAB1 NLK â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 10391247 11274345 12620219 14660645 14960582 15082531 18264787 18855897 20194509 23070005
TAB1 NLK â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 10391247 11274345 12620219 14660645 14960582 15082531 18264787 18855897 20194509 23070005
TAB2 NLK â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 10391247 11274345 12620219 14660645 14960582 15082531 18264787 18855897 20194509 23070005
NLK TCF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
NLK TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16714285 14960582 12556497 12901858 11274345 20194509 18855897
NLK TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
NLK TCF7L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
NLK TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 14960582 2861485 12556497 11274345 20194509 18855897
NLK SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21988832 19690946 23602568
NLK STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17563747 17145710 15764709 15004007
PKM STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23791887 29127353 22901803 22306293 24115444 28978186 27080861 26542452
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
RANBP2 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12727872 18439914
RANBP2 RANGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16204249 9019411 11854305 19526197 22464730 12192048 22194619 11709548 21518904
RCHY1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 21988832 19483087 17568776 24367557 25116336 21084285 12654245 21791603 20452352 19043414 16713569 31630802 27519799 19918835
SKI SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 17145710 12764135 25609649 12419246 20959473 10485843 15231748 23331499 21071413 12874272 12732634 25670202 14525983 12857746 15761153 12793438 17469184 19032343 14699069 10531062
STAT3 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 WNT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19424602 17203201
TAB2 TAB1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TAB2 TAB1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TLE1 TCF7L2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 10485845 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
TLE3 TCF7L2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 10485845 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
TLE1 TLE3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10485845 11934263 9819412 8955148 19460168 15768032 15121853 10831834 11266540 9751710
TP53 NOTCH1 â—¼   KO_DOWN_REGULATES ✅ - -1.46 1.45 PKG 28854368