Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PARP1 CUL4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
H3C2 XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 PARP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 XRCC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 EZH2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
E2F4 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799066
PARP1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
PARP1 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16647857
E2F4 AURKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 15033491
NUSAP1 CDCA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12963707
PARP1 CUL4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23045548 23319653
E2F4 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 16135806
E2F4 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 14532106
H4 PARP1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 19470756 33961781 20525793 27248496 30804502
CBX1 CBX3 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
UHRF1 CBX3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28803780 34079125
CUL4A WDR76 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30655611 17041588
WDR76 SSBP â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
SSBP XRCC5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32877691 24981860
SSBP H4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22453275 27248496
SSBP XRCC6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32877691 24981860
WDR76 TCPE â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 25817432
DCAF8 TCPH â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 TCPH â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 25817432
WDR76 DNLI3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 27248496
AURKB H31 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21397507 10949293 11756469 18477699 34079125
WDR76 DNJA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
SSA27 WDR76 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
DCAF8 TCPB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
DCAF8 TCPG â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 SIR1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 31353912
IMDH1 WDR76 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 H2A2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
WDR76 CBX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
WDR76 CBX3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
HELLS PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31417184 34079125
IKZF1 WDR76 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
WDR76 LMNA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
WDR76 MAP1B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
MYH9 WDR76 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 26496610
WDR76 PRKDC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
WDR76 RPA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31353912 27248496
WDR76 SSRP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 25817432
SSRP1 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CDCA8 KIF22 â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
TCPE SSA27 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25416956 32296183 22939629 16189514
SSA27 TCPH â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 11591653 25416956 32296183
H31 DNLI3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29568061 33961781 25281560 34079125
CBX1 H4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21888893 24981860 27248496
XPC H4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 30804502 27248496
H4 DNJA2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30804502 27248496 19862764
H31 WDR76 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31353912 25281560 27248496
KCC2D WDR76 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 27248496
WDR76 DNJA2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 31353912 27248496
CBX1 H3C2 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 16415788 5218238
H3C2 CBX1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 16415788 5218238
WDR76 XRCC6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31353912 25817432 27248496
WDR76 XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31353912 25817432 27248496
H4 UHRF1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30804502 14993289
EZH2 H31 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 33479123 16224021 16431907 34079125
H31 LMNA â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 25948554 30419336 26527279
XRCC6 SIR1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 17334224 15205477
LMNA PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29568061 25948554 30419336 22412018
PRKDC PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 20085707 16794079 21575865 9398855
AURKB CDCA8 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
PARP1 UHRF1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 31964471 24782312 34079125
CBX3 H4 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24981860 27248496 14578449 30804502 21888893
SUPT16H SSRP1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 5218941 16902406
CBX3 XRCC6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 21888893 34079125
SSRP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 34079125
XRCC6 SSRP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 30585729
TCPE TCPH â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24981860 26344197 22939629 28514442 22863883
TCPG TCPH â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 24981860 26344197 22939629 22863883 28514442 31536960
H31 XPC â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 25281560
LCOR EZH2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26496610 24981860 27705803
WDR76 GAN â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 31353912
WDR76 PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28514442 31353912 25817432 27248496
XPC PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 34079125 28760956
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
DCAF8 CUL4A â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 33288900 21145461 32235678 16949367 28514442 19295130 31155351 31973889
DNLI3 XRCC6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442 12897160 30585729
H31 PARP1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 32937373 28190768 20080577 29568061 20504901 34079125
DNJA1 DNJA2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 33957083
WDR76 TCPG â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31353912 25817432
SIR1 EZH2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 25800736 15684044 22094255
DCAF8 CUL4B â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 33288900 21145461 16949367 28514442 31155351 31973889
WDR76 HELLS â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 33288900 31353912 25817432 28514442
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
RPA1 XRCC6 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PARP1 DNLI3 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12897160 24778456 34079125
H4 WDR76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30804502 31353912 27248496
H31 PRKDC â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20080577 22404984 29568061 20504901 26527279
H31 XRCC5 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20080577 29568061 20504901 26527279 34079125
H31 XRCC6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 25281560 20080577 21187428 29568061 20504901 26527279 34079125
WDR76 TCPB â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 31353912 25817432 27248496
CUL4B EZH2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 27634302 23238014 24292684
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
AURKB CDCA8 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
H3C2 UHRF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22064703 17673620 22348533
E2F4 NUSAP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799066
XRCC5 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26496610 22404984 15520013 21679440 26446488 26344197 17308091 15941674 28154079 16857680 20711232 19303849 20023628 15758953 20085707 10750018 10446239 33005030 9312071 28345663 12393188
XRCC6 PRKDC â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 8422676 20711232 19303849 26175416 28345663 30585729 17308091 22939629 26496610 10750018 15941674 33005030 21969602 15520013 10064605 21575865 26446488
XRCC6 XRCC5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22939629 15367688 26496610 26774286 21172662 11196700 15520013 22863883 21679440 17159921 30021884 14681455 26446488 26344197 10207052 30585729 17308091 11493912 10757784 10219089 10984620 19118032 12145306 32296183 28035050 19177010 18809223 21454661 15910003 10783163 28514442 21070772 25574025 15023334 7699019 10750018 10446239 22451927 33005030 9488450 17283121 19906305
PARP1 XRCC6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
SSRP1 SUPT16H â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
SSRP1 H4 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HIPPIE 33961781 28514442 30804502 21969370
XRCC5 XRCC6 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
XRCC6 PRKDC â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 19133841
TCPE TCPG â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 33961781 24981860 26344197 22939629 28514442
TCPB TCPG â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 33961781 24981860 26344197 22939629 28514442 22863883
H31 SSRP1 â—¼   PHYSICAL_INTERACTION 0.95 0.95 HIPPIE 33961781 15616580 29568061 28514442 26527279
UHRF1 H31 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 32428527 25281560 33097091 22064703 32144273 34079125 30392931 29506131 30639225 32609811 31018966 14993289 17967883 22096602
TCPB TCPE â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 24981860 26344197 22939629 22863883 30021884
TCPB TCPH â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 24981860 26344197 22939629 28514442 22863883 30021884
H31 CBX3 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 24981860 20011120 33097091 16415788 34133717 24576085 15136563 26527279
XRCC5 XRCC6 â—¼   PHOSPHORYLATION ✅ 0.96 0.96 mint 10783163 5212534
CBX1 H31 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 15960974 16415788 15100215 11242053 15136563 29568061 11882902 26527279 16622419
PRKDC XRCC6 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
PRKDC XRCC5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
H31 H4 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 33961781 18571423 19498464 14578449 30804502 16622419 19766566 20498094 20739937 25533843 20080577 26527279 8598932 22828868 27248496 28514442 25416956 21724829 34079125 29568061 14718166 23319141 19410544
SSRP1 SUPT16H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
XRCC5 XRCC6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPA1 CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
CBX3 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15136563 20871592 20011120 24576085 19111658 16415788 26527279
CBX1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 15136563 11882902 16622419 20871592 11242053 19111658 15960974 16415788 26527279
AURKB H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 11278789 19007248 17938195 10464286 16457588 12234980 12082625 21282660 15249581 10949293 15108802 16185088 14583461 12588998 15681610 17924679 16222246 15684425 12560483 11856369
EZH2 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18022353 15196462
E2F4 AURKB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 15033491
RPA1 CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
E2F4 WDR76 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 11799066
E2F4 TOPBP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17531812 15195143
PARP1 LIG3 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 17088286 17116881 17884153 18524993 19208614 19362533 19364882 19809470 19847258 20056333 20211143 20227374 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 8264637 8978692
PARP1 LIG3 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11900249 12648680 14726013 15703371 16697054 17088286 17116881 17884153 18524993 19208614 19362533 19364882 19809470 19847258 20056333 20211143 20227374 20603072 21270334 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 8264637 8978692
PARP1 SUPT16H â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18406329 16682447
RPA1 TOPBP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 TOPBP1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 TOPBP1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CBX1 CBX1 â—¼   KO_DOWN_REGULATES ✅ - -2.99 2.98 PKG 28854368
XPC XPC â—¼   KO_DOWN_REGULATES ✅ - -3.23 3.22 PKG 28854368
PRKDC PRKDC â—¼   KO_DOWN_REGULATES ✅ - -4.22 4.21 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368