Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
RRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
RRAS FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
RRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN RRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17474147
RRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17474147
EFNB1 TIAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17440041 14988728
GRIN1 TIAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17440041 14988728
EFNB2 TIAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17440041 14988728
TIAM1 EFNB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17440041 14988728
TIAM1 GRIN2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17440041 14988728
PAK1 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
PAK3 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
PIK3R1 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033842 16982329
VAV2 VAV3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
VAV3 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
PAK1 VAV3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
PAK3 VAV3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
EFNB3 GIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 12695502
EFNB2 GIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 12695502
SRC GIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 12695502
FYN GIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 12695502
EFNB1 GIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 12695502
GIT1 ARHGEF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218539 16628223
WASL ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
EFNB2 ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ACTB EFNB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ACTB EFNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ACTB ITSN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
SRC ACTB â—¼   COLOCALIZATION 2.0 0.8 intact 7296071 19903481
SH3GL2 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EFNB2 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
WASL ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ACTG1 EFNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ACTG1 EFNB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ACTG1 ITSN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10219243 11747816
ARHGEF7 PAK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
PAK3 ARHGEF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9726964
FYN CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
SRC CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
NCK2 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12810700 12215529
CDC42 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
CDC42 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
VAV2 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994827 9032261
EFNB1 DNAJC5 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HRAS EFNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2201922 7478585
PTPN13 EFNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9920925
HRAS EFNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2201922 7478585
NCK2 EFNB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 11557983
HRAS EFNB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2201922 7478585
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 1845983
PTK2 EPHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19948216 10655584
EPHA2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 7982920
EPHA3 FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9632142
EPHB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16298995 18713744
ERBB2 VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 NCK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
KRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
HRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ERBB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
ERBB2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 8026468
WASL FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11340081 16525419
NCK2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 11557983
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN TGOLN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12670391 8621607
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
FYN VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 11262396
HCK PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
LCK HLA-DPA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
RASA1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221569 9219684
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
ITSN1 WASL â—¼   COLOCALIZATION 2.0 0.8 intact 5214632 11584276
KALRN RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9139723 21483438
PIK3R1 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220762 8246987
LYN PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PIK3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
MYC PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19602047 11509615
NCK2 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17310244 11557983
VAV2 PAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
VAV2 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
PAK3 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
RAC1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
PAK3 VAV2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
PAK3 VAV2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
PAK3 RAC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 10075701
RAC1 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9148763 10592173
PIK3CA RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9148763 10592173
TGOLN2 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
WASL PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15040784 10995436
RAC1 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18212043 18066058
SRC PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
VAV2 RAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9705280 11804587
VAV2 RHOB â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18589439 8990121
SRC SDCBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18832467 0808171105
SDCBP SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18832467 0808171105
WASL SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15040784 10995436
SRC YES1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EFNB1 EPHB1 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 11713248
PIK3R1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16273093 5218056
RHOB TIAM1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB PTN13 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
SDCB1 FYN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 31413325
TNFL8 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TNFL8 EFNB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CEA21 EPHA3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
S39A5 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TM213 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PCD12 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ZDH11 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CP054 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
EGFR ACTB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22366308 31980649
CDHR5 EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PVR EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RHOB EFNB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
EFNB2 SDC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
RGS3 EFNB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RHOB EGFR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB EPHA2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB EPHA7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB EPHB4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB GRIN1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB LYN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB SRC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
RHOB SDC2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 34079125
CDC42 TIAM1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31871319 32203420
PTN13 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 9920925
DPA1 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
DPA1 EFNB3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
AT1B3 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
TSN5 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CEA21 SRC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CEA21 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
S39A4 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
EFNB2 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
WDFY2 EFNB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
EFNB1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 22279592 33961781
EFNB2 EPHB3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
EGFR EPHA2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 15657067 24797263
PICK1 EPHA7 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
EGFR HCK â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
PTK2 YES1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
MYC ACTB â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29467282 11839798
CDC42 EPHA2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31871319 28205554 28628118
ERBB2 EPHA2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 30898150 28205554 28628118
LYN HCK â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
SDCB1 EFNB1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 9920925
EFNB1 SRC â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 8878483 16189514
EPHA7 EPHA2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 22036564
RASA1 ERBB2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24412244 16273093 22973453
SRC LYN â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22581261 32707033 18070987 9169421
PAK3 RAC1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
RHOB ROCK1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 34079125 31871319 34187934
VAV3 EGFR â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24797263 22973453 10938113 25754235 11094073
EFNB2 EPHA3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 9195962 8559144
EPHA7 EPHA3 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 33961781 28514442 22036564
ARHGEF7 CDC42 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CDC42 PIK3R1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
ITSN1 CDC42 â—¼   GTPASE_REACTION ✅ + 0.86 0.86 Signor 30540523
EFNB1 DNJC5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 29997244 33957083
ERGI1 EFNB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 26186194 34079125
EFNB2 PICK1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15458844 28514442 26186194
EFNB2 RGS3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 15458844 28514442 33961781
EGFR WASL â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
RAC1 KALRN â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9139723 21483438
HRAS PIK3CA â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EGFR VAV3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIK3R1 PTK2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ARHGEF7 RAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EGFR SH3GL2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMURF1 SMURF2 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
CDC42 RAC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
PICK1 EFNB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442 9883737 26186194
RGS3 EFNB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442 16189514 11301003
EPHB2 RASA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10644995 9233798
EPHB3 FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9674711 16713569
LYN FGR â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 32707033 31980649 34079125
HCK RASA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 7782336 16189514
SRC RASA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11389730 16189514 16713569 1717825
EGFR NCK2 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ERBB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
NCK2 GIT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 26186194
NCK2 EFNB2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12206665 16713569 15764601 12606549
EGFR FGR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
SRC FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 16966330 31980649 28514442 19711372 9169421
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EGFR PIK3R1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
EGFR RASA1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
SH3GL2 SYNJ1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ERBB2 SRC â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
VAV3 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10523675 10592173
MYC ACTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PTK2 ARHGEF28 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16298995 12702722 15378065
EFNB1 ARHGEF28 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16298995 12702722 15378065
EFNB3 ARHGEF28 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16298995 12702722 15378065
EFNB2 ARHGEF28 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16298995 12702722 15378065
MYC BLK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
ITSN1 CDC42 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11584276 12006984 15824104
SRC EFNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8878483 16189514 22279592
EFNB1 NCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11557983 16713569 16636066
NCK2 EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24658140 31980649 22973453 9843575 16713569 25402006 1333047 10026169 9737977
YES1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 22430206 11160627
EPHA3 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9632142
EPHB2 ITSN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12389031
EPHB2 SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16198615 11580899
EPHB3 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9674711
SRC ERBB2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 22973453 19704002 21075308 7542762 7797556 19372587 29720121 11940572 17875712
ERBB2 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9774445
PAK3 HRAS â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
HRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
HRAS SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15752734 16997272 32196115
ITSN1 SH3GL2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PAK3 KRAS â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
KRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
SRC KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30644389 26854235 9096340
MYC NRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PAK3 NRAS â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
NRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
PTK2 PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11119718 10592173 7537275
CDC42 PAK3 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
EPHB2 PICK1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 33961781 9883737 10839360
EGFR VAV2 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
ARHGEF7 GIT1 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
PTK2 SRC â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
NCK2 PAK1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
NCK2 EFNB1 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 16189514 11557983 16713569
FYN YES1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
ARHGEF7 PAK3 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
PAK1 ARHGEF7 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218539 16628223
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
EFNB2 EPHB4 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
PAK1 GIT1 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 25852190 16628223 31980649 23455922
SDCB1 SDC2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 18256285 31930596 9391086 22660413
EPHB2 EFNB2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 28514442 26186194 11780069
EPHB2 SRC â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 18713744 9632142 10644995
RAC1 PAK3 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 11478794 11862216 25301945
EFNB2 EPHB2 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PAK1 CDC42 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 7744004 12879077 23455922 15548653 10802735 24276241 31871319 10684602 21167153 19596003 12606577 10360579 18057010 20936779 11157984 25150978 18426980 21029865 12650940 9705280 8107774 23175184 21048135 31478661 9535855 16678097
WASL CDC42 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 31871319 16293614 9422512 10781580 20936779 21311754 10724160 11943145 11331876 15834156
SRC EGFR â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 22227249 17284441 24658140 17158602 21278788 20333651 28065597 7527393 7797556 10777553 16713569 20624308 23175185 7506422 22973453 20935677 24189400 11983694 10075741 31980649 19704002 10358079 10971656 21268077 9020193 25402006 21573184 8845374
WASL ITSN1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 11584276 18539136
PIK3R1 PIK3CA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20018188 7383613
CDC42 ITSN1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CDC42 WASL â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HRAS RASA1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
RAC1 PAK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5217506 15688026
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ARHGEF7 PAK1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
GRIN1 GRIN2B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CDC42 PAK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PAK1 RAC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PIK3CA PIK3R1 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
EPHB2 RRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10570155 11682467
SRC RRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17474147 15212693 10570155 11682467
TIAM1 RAC1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11955434 12447393 12829230 15611338 15967165 20841469
HRAS TIAM1 â—¼   UP_REGULATES ✅ + 15.0 1.0 ACSN 10358164 12134164 12447393 14764585 16102570 17673906 20841469 24027568 24954210 7510700 7673236 8551221 9069260 9763606 9846483
SRC TIAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12810717 19285946
HRAS TIAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9069260 7673236 16203995 12134164 18568040
TIAM1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7753201 11130063 15611338 32203420 11955434 15967165 8910315 10592173 12393875 11595749 10212259 12829230
SRC VAV3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17686471 8986718 11007481 10395673 9099726
SRC VAV3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17998938 11917103
SRC GIT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14523024 24699139 22302306 20689073 17570479
ARHGEF7 GIT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10428811 21295525 12473661 10896954 16628223 16787945 10592173 12695502
GIT1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938112 12473661 12629171 24608434 16713569
RHOC ACTB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21576392 15507212 22275430 16439214 23222643 24914801 22094460
ACTB CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
CDC42 ACTG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
RAC1 ACTG1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 18391171 16262445 11231582 9600938 15040784 12743368
RHOC ACTG1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21576392 15507212 22275430 16439214 23222643 24914801 22094460
PAK1 ARHGEF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 20936779 16101281 11096073 10330411 11157752 16628223 9726964 16492808 9659915 10592173 16407834 17392278 29997244 32814053 25472536 23455922
ARHGEF7 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 24792722 16983070 18684957 16492808 9659915 10592173 14557270 11309380
ARHGEF7 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15649357 16983070 9659915 25150978
BLK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11369622 15728464 12590707 10753828
BLK EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 31980649 16273093 24658140 11160627 25402006
VAV2 CDC42 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10934226 11080163 11262396 12094222 14623913 15365099 15886116 9822605
SRC CDC42 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
PIK3R1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
SRC CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14506284 26816343 9626657
ITSN1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 30540523 23331499 11584276 15824104 12006984
CDC42 PAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11157984 20936779 10934474 10559936 11413130 11950587 11248548 15824104 15020669 18719708 10613909 10866202 11340065 15003621 10461188
CDC42 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
CDC42 WASL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17145710 10559936 11331876 10940259 9422512 11943145 10511705 15020669 8625410 11340065 10219243 15003621 15834156 16293614 20936779 10934474 11413130 15713627 11950587 10724160 10467124 10781580 11248548 18719708 10613909 10461188
CDC42 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 810774 10360579 21167153 8107774 10559936 9705280 12650940 16678097 23331499 21029865 10684602 18057010 15020669 21070974 11340065 21048135 15003621 20936779 10934474 11413130 15788770 15713627 9535855 23109003 11950587 19628037 7744004 12879077 12606577 24276241 10224076 19596003 8973630 19812368 11248548 10802735 18719708 10613909 10461188 23455922
EFNB1 EPHB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24003208 15114347 11114742 9330863
EFNB1 EPHB6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24003208 15114347 11114742 11713248
EFNB1 EPHB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 24003208 15114347 9576626 11114742 9330863
EFNB1 EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 24003208 8878483 15114347 9576626 11114742 93308638878483 9330863
EFNB1 EPHB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10669731 23331499 24003208 9267020 15114347 11114742 12223469 11713248 9330863
EFNB2 EPHB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 24003208 15114347 9576626 10066262 11114742 8559144 9330863
EFNB2 EPHB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 23331499 7534404 24003208 15114347 9576626 9718367 11114742 26481148 18988627 12051776
EFNB2 EPHA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 32589946 9195962 8559144
EFNB2 EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 24003208 9267020 15114347 28719605 11114742 933086311780069 11780069 9330863
EFNB2 EPHB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 24003208 15114347 9576626 11114742 8559144 9330863
EFNB3 EPHB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 9484836 24003208 21071413 9267020 15114347 11114742 18988627 93308639484836 9330863
HCK EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 31980649 24658140 11160627 25402006 23397142
FGR EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 31980649 24658140 11160627 25402006
LYN EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 31980649 16799092 23866081 24658140 11160627 23764002 25402006 22430206
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17389395 19531499 11516622 26910843 10938113 10618391 12577067 12454019 17016520
EGFR MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12556561 15531749
EGFR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16713569 16919435 25402006 10806474 29435030 20473329 7657702 19339212 17496910 15657067 24658140 19625610 7529872 20802513 31980649 10545505 24043698 15951569
EGFR RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8647858 16273093 7991458 1850098 17570479 1633149 1385407
EGFR NCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 1333047 23331499 10026169 9737977 24658140 16713569 25402006 9843575 1333046
EGFR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17496910 26918608 7797556 25241761 19531499 16273093 8662998 14967450 16713569 21701776
SRC EPHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24457997 28957431 26788993
EPHB2 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9233798 10644995 23331499
EPHB2 SYNJ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15821731 23331499
EPHB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18713744 10644995 9632142
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
ERBB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17496910 19617202 25241761 10545505 7657702 27638858 19339212 27939360 15743500 20201928 12753909 16919435 16713569 7529872 12600989 11807823
ERBB2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 17496910 11546794 23331499 9756944 16273093 1351056 15680399 11331299 21075308 16843263
ERBB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16769082 19617202 11940572 12753909 21075308 7542762
ERBB2 RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16273093 24412244
FGR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 32051585 27790061 12590707 28692661 14610060 15728464 12495636 28377405 10593973 16510472 11369622 14603053 26710849 9148935 20160475 29743287 24608426 12408869 14572662 24655477 26530902 34237080 11438458 12659633 26068982 15126359 14978737 18676832 27270311 12023386 11331870 15800067 23109003 7597091 33674746 8051157 11891289 22761432 19962670 20180147 24858039 11035755 10753828 11857088 15611137 7529876 15389641 33715263 15077193 17234784 8824286 34161758 10821872 12754219 12087088 15316068 22751010 32049010 12531888 12387730
FGR PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
FYN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 11369622 12558988 15494733 20151426 12590707 16293639 7505391 15728464 11278857 16713569 10753828 15494732 10085136 15494734
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
FYN GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 12451687 19477150 18673451 16713569 11024032 23162743 21686074 24611998 16190898 10458595 28497343 20722721 19874789 11483655 22009355 23127881 21896318 20053906 19482714 18932218 26229100 18691323
GRIN2B GRIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12191494 19487695 15030493 8139656
SRC GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10884433 18184784 11483655 11024032
HCK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11369622 12590707 23109003 15728464 9148935 12495636 10753828 25814554 7529876 10593973
HCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 21780115 11526404 15032589 23109003 12029088 22880054 10488096
LCK HLA-DPA1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DPA1 SH3GL2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8397411 10480952 9202021 15749704
VAV2 HRAS â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10934226 11080163 11262396 12094222 14623913 15365099 15886116 16713974 9822605
RASA1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10769036 11389730 23331499 18829532 7628625 9219684 10592173 8663024 16713569 26721396 8360177 8537347 1904555 10394594 2833817
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
HRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9069260 9113989 8052307 24412244 17540175 9931431 11313862 14724584 10592173 9150145 8665852 10783161
KRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
LCK VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11516622 12400014 17570479 12454019
LCK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8294442 11337495 8246987 14583609 11526404 15032589 23109003 9461588 7504174 8397196 10488096
LCK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11369622 12590707 15728464 9257837 10753828
LCK RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 11389730 1850098
LYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21780115 29145629 12506011 18453587 11526404 10455108 15032589 23109003 23180781 9334184 15149544 10194437 22880054 11598010 10488096
LYN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9169439 11369622 11389892 12590707 23109003 15728464 9148935 12495636 10753828 25814554 7529876 10593973
NRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
PAK1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 18593598 27542844 21371233 22105362 22981863 18668521 27169363 12876277 31416844 23331499 33789117 7873542 29551131 28225038 19595712 11435472 9351825 25794709 9416003 21248166 14993270 23701950 18940914 16129686 11948406 23162738
RAC1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 18000759 15574420 19151919 11777939 18855897 21614932 12738796 11274345 12040186 19568798 14585353
MAP4K4 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 9890973 10807933
PAK1 NCK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 26186194 10026169 25416956 10592173 31515488 11557983 32296183 16713569
NCK2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 10592173 11950595 16713569
NCK2 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 26186194 10026169 25416956 10592173 31515488 11557983 32296183 16713569
NRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
NRAS PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8052307 7820549 9150145 8665852 21779497
RAC1 PAK1 â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
RAC1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 130.0 1.0 Omnipath 17145710 15229651 21167153 8107774 24792722 16551621 14579272 10023776 8805275 18325335 11134022 19693014 19277120 21474670 12650940 15673687 19961560 20711231 11950930 16678097 12123608 19270716 9744077 9148763 11689432 23331499 21029865 16368433 11121431 16492808 15075243 21454543 10592173 24172987 15212766 7493928 10793146 21070974 10706722 8910277 17245428 25819133 20936779 11030651 9989831 15157156 9535855 19359598 25150978 16049136 18854161 19628037 15688026 12879077 7744004 11728826 16002993 9764820 9032259 25843002 10224076 19732720 19596003 10802735 19893577 16212495 11130076 12480336 11152757 19327867 22117219 22581261
RAC1 PAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9744077 10023776 8805275 16212495 12480336 11152757 25301945 11728826 11478794 8910277
SRC PIK3CA â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12682286 15314172 20861220 18657504 11689445 12431978 25587652 11044445 22266855 11029403 11029009
SRC PIK3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12750372 10592173 17275257 10830300
PTK2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10806474 8649427 7537275 10973983 12554777 16713569 9416004 19889638
PIK3R1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7629060 8034624 12086876 12515821
SRC PTK2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11476890 12531888 16919435 17496910 17517963 20027185 25572304 26552706 27216177 8892616
SRC PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 216.0 1.0 Omnipath 27351421 23242524 16254240 12370821 21940449 26142360 17525734 10593973 14604860 17389395 19171305 22402981 19339212 22353809 9748249 8941336 17570479 12464388 25226367 15611085 15817476 25241761 26393679 27978555 26833789 11927607 17828307 25913180 26866924 15247219 10085298 12387730 19055942 9507031 21454698 10973994 32814053 21057587 27931517 27438371 18793427 19695571 15735019 18560762 10592173 25319025 24389213 21852560 26689988 14984767 7505391 19568240 20103658 20822514 25868388 23275294 28423510 23764511 19625610 15561106 17192257 19138410 19369195 17088251 12753909 28701735 29190494 17016520 15598735 18814847 11821402 11418135 15728464 16291744 25067788 11602246 16713569 22287273 9032297 7997267 12960434 11369622 20616959 26079101 19534553 10931187 22710722 20068231 25866790 21347260 9822703 28202937 16153436 11980671 21855630 19826415 18464795 7529876 20621036 9330873 21473875 9425168 28956212 12615911 15951569 25814554 12876384 17438336 15212693 16966330 20705914 20847951 23729178 20407018 12558988 25127991 25918719 12590707 16360410 8054685 18814027 11696015 22800863 17117420 12495636 11278488 9864370 21776383 18083107 22814579 22194915 20515733 11119718 9148935 10428489 15743500 20655298 23065768 28213315 26923073 24015220 17289681 12110680 22006118 24164353 23109003 18935208 10753828 18233957 8816475 25118939 19664994 25530216 16760434 9330875 21266176 21034468
ROCK1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9182576 22348083 16254240 15247219 16760434 10744763 17745990 7529876 12960434
YES1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11369622 12558988 16293639 12590707 25868388 15728464 25416956 32296183 10753828 23397142
PTK2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20936779 22163037 26816343 29036929 34252134
VAV2 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8990121 32203420 11790798 10592173 10982832 16397238
SRC RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22163037 17991704 21798346 26816343 29036929
SRC RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 11389730 1717825 16713569
SRC SORBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19891780 20841568
SRC VAV2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17686471 8986718 11007481 10395673 9099726
SRC VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1531699 23118862 23457577 17570479 1311423