Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
RYBP H2AC11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219279 17070805
H2AC11 IL33 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6802671 18688256
H2AC11 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
E2F4 H2AC11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799066
H2AC11 RYBP â—¼   COLOCALIZATION 2.0 0.8 intact 5219279 17070805
YWHAZ H3C2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19766566 8009287
H3C2 XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 PARP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
H3C2 XRCC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20080577 0913709107
EED H3C2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H3C2 EZH2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
E2F4 H3C2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799066
PARP1 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
HMGN2 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
EED H4C6 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
H4C6 EZH2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17344414 17210787
E2F1 H4C6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12629508
PARP1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
HDAC1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10220385
RYBP BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
EZH2 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21465172 19351856
E2F4 BUB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15574595 18319725
DZIP3 SSRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18206970
E2F1 TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7734951
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
E2F1 HSPA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18840615
E2F1 XPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19376752
E2F4 TOP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 NAP1L4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 EED â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 14532106
E2F4 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18319725 14532106
RNF8 RNF168 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20385750
RUVBL2 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
RYBP UBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53BP1 UBB â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
XRCC6 YWHAZ â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
POLB HMGN2 â—¼   KO_UP_REGULATES ✅ + 0.8 0.8 PKG 28854368
BMI1 PARP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34316702 20668194
SDC2 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SSRP1 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
XRCC6 XPC â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
APLF SSRP1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
APLF XPC â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
BMI1 XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 34316702 24457600 20668194
XRCC5 TOP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21679440 28415827
TOP1 TP53BP1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
RNF168 UBB â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
BMI1 EED â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 23238014 24457600
SUPT16H SSRP1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 5218941 16902406
PARP1 HDAC1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 19470756 34079125 16204234 20596014
SSRP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 34079125
XRCC6 SSRP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 28514442 30585729
HDAC1 RUVBL2 â—¼   PHYSICAL_INTERACTION 869.0 0.86 STRING 36370105
TP53BP1 H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 16415788 5218238
H4C6 TP53BP1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 16415788 5218238
E2F4 HDAC1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 9724731 23060449 9858615 21102443
HDAC1 E4F1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 12730668 21666599
XPC PARP1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 34079125 28760956
APLF PARP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
NAP1L1 NAP1L4 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
RNF168 TP53BP1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
H3C2 H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 7219095 19498464
PARP1 APLF â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26186194 17396150 18172500 20098424 28514442 27067600
PARP1 E2F1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20133863 14627987
BMI1 RYBP â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
XRCC5 APLF â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17396150 20098424 26186194 23178593 28514442
E2F1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23796898 17360938 16582100
E2F4 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14576826 10208422
E2F1 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18840615
E2F4 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
RPS6KA5 EZH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TOP1 PARP1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15247263 15848144 34079125
XRCC6 XRCC5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22939629 15367688 26496610 26774286 21172662 11196700 15520013 22863883 21679440 17159921 30021884 14681455 26446488 26344197 10207052 30585729 17308091 11493912 10757784 10219089 10984620 19118032 12145306 32296183 28035050 19177010 18809223 21454661 15910003 10783163 28514442 21070772 25574025 15023334 7699019 10750018 10446239 22451927 33005030 9488450 17283121 19906305
PARP1 XRCC6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
EZH2 EED â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 24981860
EED HDAC1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
SSRP1 SUPT16H â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
XRCC5 XRCC6 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
EZH2 HDAC1 â—¼   PHYSICAL_INTERACTION 939.0 0.93 STRING 36370105
RNF2 BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16710298 5218667
RYBP RNF2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 24981860
XRCC5 XRCC6 â—¼   PHOSPHORYLATION ✅ 0.96 0.96 mint 10783163 5212534
APLF XRCC6 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
APLF XRCC5 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
SSRP1 SUPT16H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
XRCC5 XRCC6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BMI1 RNF2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
EED EZH2 â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
RNF2 RYBP â—¼   PHYSICAL_INTERACTION 999.0 0.99 STRING 36370105
PARP1 POLB â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 POLB â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
BUB1 H2AC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14667408 11756469 19965387
RPS6KA5 H2AC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15010469
RPS6KA5 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20129940 10464286 15994958 14625384 10469656
EZH2 H3C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18022353 15196462
XRCC5 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
E2F4 H4C6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 11799066
H4C6 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 23760478 25579814 23377543 25651062 17190600 27153538 18296440 22373579 19218832 16415788
APLF PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18172500 17396150 20098424
HDAC1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
BMI1 RNF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16710298 22493164 22902369 20068231 22325352 25355358 17157253 16751658 26496610 16714294 26468281 26151332 12183370 12589020 21772249 25843776 20601937 32296183 21676867 27647897 15563468 27705803 16359901 24457600 19636380
BRCC3 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
PARP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14627987 20133863
E2F1 EED â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
E2F1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18319725 14532106
HDAC1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
HDAC1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
PARP1 SUPT16H â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18406329 16682447
PARP1 TOP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 20875401 15911331 15848144 14699148 15247263
PRKCB SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244383 19901323 17570479
XRCC6 RNF168 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC5 RNF168 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
RNF8 XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
RNF8 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18001824 18006705 19203579 19772495
XRCC6 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC5 TP53BP1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XPC XPC â—¼   KO_DOWN_REGULATES ✅ - -3.23 3.22 PKG 28854368
POLB POLB â—¼   KO_DOWN_REGULATES ✅ - -7.24 7.23 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368
TP53BP1 TP53BP1 â—¼   KO_DOWN_REGULATES ✅ - -9.54 9.53 PKG 28854368