Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
H2AX H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
H2AX RAD51 â—¼   COLOCALIZATION 2.0 0.8 intact 8149296 21317870
NUDT18 GNMT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
IDO1 DDX24 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PAFAH1B3 DDX24 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RECQL4 APEX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19567405
MFAP1 DHX38 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
RAD50 MRE11 â—¼   COLOCALIZATION 2.0 0.8 intact 7114538 19197236
PARP1 MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18025084
H1-1 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16628214 5218530
PARP1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
SNCB PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TERF1 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
TERF2 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
XRCC6 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ESR1 ADA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11357058 18414489
AIMP2 PML â—¼   COLOCALIZATION 2.0 0.8 intact 8145365 21285945
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TERF2IP AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PRKACA ARPP21 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10854908
PML BANP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20075864 7893041
MCPH1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15220350
CRK BUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RIF1 CCDC106 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RAPGEF1 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8621483 5220979
PRX CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ESR1 HMGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17922863 18414489
PRKACA GPKOW â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21880142
HMGB3 HMGB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RIF1 HMGB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TYK2 HNRNPK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29892012 25416956
PARP1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MCPH1 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19525936
RAD50 NBN â—¼   COLOCALIZATION 2.0 0.8 intact 7114538 19197236
SMC2 NCAPH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17268547 5219584
NPSR1 TERF2IP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
NSMCE2 TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19308705
NSMCE2 TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19308705
NSMCE2 TINF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19308705
NSMCE2 TERF2IP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19308705
NUDT14 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216198 12620389
TERF2IP ORC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16799465 5218770
TERF1 ORC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16799465 5218770
XRCC6 PAFAH1B3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 PAFAH1B3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RALGDS RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0808110105 19075231
SMC4 SMC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17268547 5219584
TERF2IP TERF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
TERF1 TNKS â—¼   COLOCALIZATION 2.0 0.8 intact 7987670 20696165
XRCC6 TNKS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
DHX38 MAGOHB â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
BABAM1 TNKS â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
RAD50 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 10426999
MRE11 H2AX â—¼   COLOCALIZATION ✅ 0.81 0.81 mint 22157895 8303386
ESR1 TSC2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 15039427 15851513
RAD51 MCPH1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 20107607 32735676 19549900
CTBP1 H2AX â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34133714 31041561
H2AX RAD50 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 15201865 31501894 16377563 10959836 18583988 19234442
MRE11 NBN â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
AKT1 UCHL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25640309 16027165
BRCA1 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26831064 34079125
ESR1 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31527615 19805454
XRCC6 APEX1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30585729 34079125
APEX1 RIF1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28986522 34079125
ARL4C TERF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ARL4D TERF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ORC2 BRCA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25184681 17525332
BRCA1 TINF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34112789 29656893
ESR1 CTBP1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
ESR1 SMC4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26166704 31527615
HMGB1 SP100 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
NBN TERF2IP â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MCM2 H2AX â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 25963833
H2AX PPM1G â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 18406329 24981860
H2AX XRCC5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 20085707 21679440 18406329
STN1 ORC2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
BRCA1 TERF1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 29656893 34112789
BRCA1 TERF2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19797051 25184681 29656893 34112789
XRCC6 ORC2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30585729 31160578 15910003
AKT1 BRCA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
PARP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 34079125 26831064 25252691
ESR1 SET â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 20348541
MDC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
MDC1 RAD51 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 28973861 16186822
NBN SLC16A3 â—¼   KO_DOWN_REGULATES ✅ - -0.85 0.84 PKG 28854368
H2AX XRCC6 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 15613478 33961781 23145133 20224553 28514442 18406329
SET APEX1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12524539 16189514 12628186
BANP PML â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 22013068 20075864
MCPH1 TERF2 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
H2AX NBN â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6805208 18583988
NBN H2AX â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22157895 8303386
H2AX NBN â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22565321 8391733
ACD TERF2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 15383534 16880378 15231715
PPM1G PARP1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 27880917 34079125
SET PTMA â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16189514 15556635
TERF2 H2AX â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21044950 22157895 21824286
H2AX RAD51 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 21317870 28190324 30560944 31009828 10959836 28796254 29499138
BRCA1 MRE11A â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PIAS1 ESR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31527615 11117529 15666801
POT1 TERF2IP â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PPM1G XRCC6 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 28330616 30585729
TERF2IP TINF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MRE11A TERF2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
RAD50 TERF2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
POT1 TERF1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ACD TERF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ACD TERF2IP â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MRE11A TERF2IP â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RAD50 TERF2IP â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 NBN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PACSIN2 PACSIN3 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
TERF2 XRCC6 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
H2AX MRE11 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12419185 15201865 31501894 16377563 22157895 18583988 19234442
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CTBP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11751867 10196224 16713569 21102443 31636387
PARP1 HMGB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 28190768 29721183 34079125
XRCC6 SET â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 30585729 22863883 27626385
ESR1 HSPA4 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MDC1 MRE11A â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PARP1 XRCC5 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
NCAPD3 SMC4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
XRCC5 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
H2AX PARP1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28796254 28242625 16377563 27728808 18406329 28514442 20000738 20085707 16522924
TERF2 MRE11 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18212065 22939629 10888888 19287395
MRE11 XRCC6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 30585729 10508516 26344197
AKT1 TSC2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12167664 15342917 12438239 12150915
MDC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 17525332 15569676 29656893 12607005 19766185 12611903
NBN BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10426999 29656893 10783165 11504724 25659039 25939603 25184681 19244116 18171670 12124328
MRE11A XRCC6 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
TERF2 NBN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22939629 10888888 19287395
TERF2 ORC2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 16799465 18761675
XRCC6 TERF2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 10984620 26496610 21044950
MDC1 RAD50 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
POT1 TINF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
TERF1 TNKS â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
MFAP1 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
MDC1 H2AX â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 21622030 21293379 15201865 20159462 18001825 28242625 26734725 16377563 12607005 18001824 14519663 30598506 18583988 32518374 12475977 21676867 19234442 29499138
NBN H2AX â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 16932743 12419185 11110662 15201865 18001825 31501894 20081839 23145133 16377563 18001824 22157895 18583988 22941933 21676867 15733840
H2AX BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18344987 12419185 26095369 20681793 19805520 18001825 31501894 26121674 10959836 12485996 18001824 19766185 11927591 34321665 29499138
H2AX MCPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17599047 22154951
MDC1 MRE11 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12607003 30179224 29656893 20081839 12607005 14519663 18583988
BRCA1 MRE11 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10426999 11353843 17349954 23530059 24413181 16391231 29656893 11504724 25184681 10783165
NBN MRE11 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 12750284 12419185 24413181 21884979 24981860 22939629 12679336 10426999 28369484 17526493 9705271 26455393 12607003 17612497 12447395 22464731 22078559 22231403 34348893 28363998 11062235 15758953 11238951 23530059 33558481 15734743 34038735 30179224 12861053 18458108 19270065 17500065 10783165 30440001 22941933 19244116
TINF2 ACD â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15383534 28514442 33961781 21044950 32296183 25910212 15231715 26496610 16880378 16713569 25416956 15181449 16189514
RAD51 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11498787 31270457 19369211 14636569 24085845 29656893 28319063 25659039 34408138 31009828 9774970 16713569 25499220 19766185 17302439 9008167 28976962
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
ESR1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11457657 10949931 17068199
MPG ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17129768 14761960
SET MCPH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18718915 21515671 21911480
MRE11A XRCC5 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
TERF2 RAD50 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18212065 22939629 10888888 19287395 15100233
RASA1 XRCC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
XRCC6 XRCC5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 22939629 15367688 26496610 26774286 21172662 11196700 15520013 22863883 21679440 17159921 30021884 14681455 26446488 26344197 10207052 30585729 17308091 11493912 10757784 10219089 10984620 19118032 12145306 32296183 28035050 19177010 18809223 21454661 15910003 10783163 28514442 21070772 25574025 15023334 7699019 10750018 10446239 22451927 33005030 9488450 17283121 19906305
NCAPD3 NCAPG2 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PARP1 XRCC6 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
GPKOW ZRANB1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
ACD TINF2 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
MDC1 NBN â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
XRCC5 XRCC6 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
NBN RAD50 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
BRAF RAF1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
TERF1 TINF2 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
NCAPH2 SMC4 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
NCAPG2 NCAPH2 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
SMC2 SMC4 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
NCAPD3 SMC2 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
MRE11A NBN â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
RAF1 BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 8396417 22510884
ORC2 MCM2 â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 16189514 12614612 15232106
XRCC5 XRCC6 â—¼   PHOSPHORYLATION ✅ 0.96 0.96 mint 10783163 5212534
NCAPH2 SMC2 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
H2AX MDC1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6805208 18583988
NBN MDC1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20224574 7891431
RAD50 NBN â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 24981860 19197236 22939629 12679336 10426999 26344197 17526493 9705271 12607003 17612497 12447395 22464731 34348893 11062235 15758953 12124328 11238951 26215093 23530059 15734743 16391231 24651726 30179224 17500065 30440001 22941933 10783165
TINF2 TERF1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 10581025 15383534 28514442 21044950 19487455 33961781 15316005 11701125 26496610 16880378 16169070 15133513 26186194 20811636 17589526 25416956 15181449 28216227
TERF2IP TERF2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8286516 21829167
NCAPD3 NCAPH2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
DCLRE1B TERF2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
NBN TERF2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SLX4 TERF2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
TERF2 TINF2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
TERF2 TERF2IP â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RAD50 MRE11 â—¼   PHYSICAL_INTERACTION 0.99 0.99 HIPPIE 12750284 24413181 24981860 19197236 22939629 31501894 30733337 10508516 26344197 8756642 28369484 9705271 26455393 12607003 16163361 11504724 34348893 28363998 11062235 26215093 27173435 23530059 33558481 15734743 16391231 24651726 17694070 34038735 17500065 19270065 30179224 10888888 10783165
MCM2 ORC2 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
MRE11A RAD50 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SMC2 SMC4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ACD POT1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
XRCC5 XRCC6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BUB1 H2AC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14667408 11756469 19965387
XRCC5 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 H2AX â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H2AX RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
BRCA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18001824 18001825 17145710 12419185
H2AX MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21676867 14519663 18001824 21293379 16427009 16377563 18583988 21622030 18001825 12607005 19234442 20159462 15201865
XRCC5 MRE11 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 MRE11 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MRE11 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
MRE11 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
RAD50 MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19197236 16163361 10888888 8756642 17713585
MRE11 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 22464731 26455393 12861053 17500065 15734743 12419185 19270065 22078559 19244116 21884979 12679336 11238951 12607003 9705271 17713585 10783165 12447395 10426999 18458108 15758953
PARP1 H1-1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18250087 18851700 18927583
XRCC5 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
NBN H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
XRCC6 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
H4C6 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
H4C6 DNMT3A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16357870 24074865 23326524 12435631 22466170
H4C6 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
ACD TINF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25910212 16880378 15181449 25416956 21044950 15383534 31515488 26496610 16713569 15231715
AKT1 TSC2 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
AKT1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19651622 20058876 14688280 11510412 25241761 20230923 20068231 18452278 11410590 17570479 10869359 18669648
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15184909 25241761 22689577 15856005 10485711 17660512
AKT1 PEA15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 20166139 17700518 18767875 19413330 19664995 30569123 18578522 21285289 20068231 18452278 16189514 18669648 32047549 25416196 17287340 17227770 19651622 12808093 9721757 18212344
AKT1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 75.0 1.0 Omnipath 16873412 12820960 17018601 11756412 32308763 11923280 16697215 19690332 21893193 20398329 18372248 21177249 12438239 18466115 15808505 29042482 20138985 15342917 17597835 20214616 12271141 16702951 20837138 17570479 26844273 15169778 17386266 10949026 16288292 24590173 11715018 15661536 18636226 18411301 20028854 9812896 16636147 20169078 17680028 12172553 19664994 18707149 10722653 12150915 18570873 20832730 12364343 17052453 18283331 21666717 27451907
AKT1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17428466 20832017 20085797 21242970 17570479 10542266
PARP1 APEX1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17548475 11440997 12727891 15135726 10364231 11340072 9804757
APEX1 POLD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
BABAM1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19261748 19261749
PRKACA BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11510412 10931830
BRCA1 RAD50 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 PARP1 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 PARP1 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 RAD50 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 BUB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
RAD50 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10783165 16260778 16391231 10426999 11504724 25084169 25184681 16713569
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
CRK RAPGEF1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRK RAPGEF1 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRK RAPGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 8621483 9560161 9122199 17515907 10592173 11870224 9591773 18835194 8943292 7512734 19001122 7806500 20697350 7531694 12054111 19380743 17474147
DCLRE1B TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21217703 18468965 20479256 26496610 16606622 18469862 16730175
ESR1 PTMA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10938099 12149645 11459795
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
PRKACA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22266331 9891036 15193262
HMGB1 IL1RN â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26618107 27048821 27192565
RAD50 MDC1 â—¼   PHYSICAL_INTERACTION 59.0 1.0 ACSN 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 7575488 9407949 9488723
XRCC5 MDC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 MDC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
MDC1 RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
RAD50 MDC1 â—¼   SHARES_COMPLEX 59.0 1.0 ACSN 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 7575488 9407949 9488723
MDC1 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 15201865 20460517 23115235 14519663 18001824 18678890 19804756 18583988 19230643 12607003 12607005 20224574
NBN RIF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
NBN PARP1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
NBN XRCC6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
PARP1 RAD50 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
PARP1 RAD50 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
TINF2 POT1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 POT1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
POT1 TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TNKS POT1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17825467 21181822 21818122 22433952 22634377 9822378
PRKACA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19007248 11971957 20166139 18767875 20230923 9001246 10576742 23331499 20068231 7935389 18669648 18691976 9922370 15664191 19651622 12801936 9091312 10862777 9710607 11997508
RIF1 RAD50 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15468306 15574327 23333306 23306437 15723659 23727112
XRCC5 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC6 RIF1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC5 RIF1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
TNKS TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 23583392 12080061 20811636 26186194 11854288 11739745 22153077 10988299 15133513 20696165 22645305 26496610 11802774 9822378
TINF2 TERF2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 TERF2 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TNKS TERF2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17825467 21181822 21818122 22433952 22634377 9822378
TERF2 TERF2IP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 17145710 19651898 15316005 27214791 10888888 21217703 19287395 15383534 26496610 23086976 19164295 15100233 16880378 26450775 21829167 10850490 28082411 23307557 21044950 14565979
TINF2 TNKS â—¼   PHYSICAL_INTERACTION 12.0 1.0 ACSN 10581025 15133513 16166375 17825467 18680434 19965504 21181822 21818122 22433952 22634377 7502076 9822378
TINF2 TNKS â—¼   SHARES_COMPLEX 12.0 1.0 ACSN 10581025 15133513 16166375 17825467 18680434 19965504 21181822 21818122 22433952 22634377 7502076 9822378
TINF2 TNKS â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10581025 15133513 16166375 17825467 18680434 19965504 21181822 21818122 22433952 22634377 7502076 9822378
MDC1 TERF2 â—¼   KO_DOWN_REGULATES ✅ - -1.08 1.07 PKG 28854368
RECQL4 SLC16A3 â—¼   KO_UP_REGULATES ✅ + 1.22 1.22 PKG 28854368
RECQL4 RECQL4 â—¼   KO_DOWN_REGULATES ✅ - -2.61 2.61 PKG 28854368
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
NBN NBN â—¼   KO_DOWN_REGULATES ✅ - -6.31 6.3 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368